From Science Daily:
A UCF College of Medicine researcher has identified for the first time a tiny liver protein that when disrupted can lead to the nation’s top killer — cardiovascular disease — as well as fatty liver disease, a precursor to cancer.
The chief culprit in disabling the protein’s delicate mechanics is a fatty acid found in red meat and butter.
Dr. Shadab Siddiqi’s discovery is the cover story of the June 10 edition of The Journal of Biological Chemistry. An associate professor in the medical school’s Burnett School of Biomedical Sciences, Siddiqi’s work focuses on how to prevent heart disease by regulating the secretion of very low density lipoproteins (VLDL) by the liver. These lipoproteins are known to increase cholesterol levels, a risk factor for plaque buildup in the arteries. His previous research has discovered how newly formed VLDLs are transported into the blood stream, forming plaque.
For healthy liver function, normal VLDL secretion must be kept in a delicate balance. Too little VLDL secretion causes fatty liver and, potentially, liver cancer. Identifying the protein and what activates it is the first step in finding ways to prevent its malfunction and disease.
Since changing diets is so difficult, Siddiqi hopes to find an easier alternative.
In a study funded by the National Institutes of Health, Siddiqi discovered a tiny protein — called a Small Valosin-Containing Protein
Interacting Protein (SVIP) — that regulates how much VLDL is secreted into the blood. SVIP in the liver must be regulated properly to ensure optimum…